Design, development and validation of a standalone Perfusion Bioreactor for Endothelial Cell Cultivation
The thesis is based at the Mechanobiology lab. ( Department of Chemistry – Politecnico di Milano – campus Leonardo) with the possibility to perform positron annihilation spectroscopy measurements at the Positrons lab (Department of Physics – Politecnico di Milano – Como). The work is experimental and computational. It consists in the optimization and realization of a novel system for interfacing biological matter and accelerated antimatter particles. The candidate will improve the design of a pre-existing device by using CAD softwares (e.g. Inventor, Solidworks) and Multiphysics simulations (e.g. COMSOL). The candidate will be involved also in the prototype realization with additive manufacturing techniques (SLA-DLP) and replica molding, and its functional validation with living cells. The ideal candidate should have a good knowledge of CAD designing and fluidic transport phenomena.
The thesis is based at the Mechanobiology lab. ( Department of Chemistry – Politecnico di Milano – campus Leonardo) with the possibility to perform positron annihilation spectroscopy measurements at the Positrons lab (Department of Physics – Politecnico di Milano – Como).
The work is experimental and computational. It consists in the optimization and realization of a novel system for interfacing biological matter and accelerated antimatter particles. The candidate will improve the design of a pre-existing device by using CAD softwares (e.g. Inventor, Solidworks) and Multiphysics simulations (e.g. COMSOL). The candidate will be involved also in the prototype realization with additive manufacturing techniques (SLA-DLP) and replica molding, and its functional validation with living cells.
The ideal candidate should have a good knowledge of CAD designing and fluidic transport phenomena.
Tutors: Ing. Matteo Vicini, Prof. Rafael Ferragut, Prof. Manuela T. Raimondi, Prof. Claudio Conci
Interested in this topic?
Specific thesis goal can be shaped around your background and timeline. Send your short bio and your motivation, and we will arrange an informal chat.
